Practical synthesis of C-aryl glycosides via redox-neutral Borono–Catellani reaction

Abstract

Herein, we describe a practical Borono–Catellani strategy for the efficient synthesis of C-aryl glycosides, with readily available arylboronic esters and glycosyl chlorides as the building blocks. It features mild reaction conditions, excellent diastereoselectivities, and good functional group tolerance. A diverse array of highly decorated C-(hetero)aryl glycosides are obtained in a convergent and redox-neutral manner.