Issue 7, 2025
From the journal:

Chemical Communications

Cu-MOF-based targeted nanomedicine utilizing biorthogonally catalyzed chemotherapy and chemodynamic therapy with spatiotemporal orchestration to treat hepatocellular carcinoma†

Xiuyan Wan,‡a   Yu Zhang,‡a   Huiwen Zhang,a   Wei Pan, ORCID logo a   Xincheng Qiao,a   Na Li ORCID logo *a  and  Bo Tang ORCID logo *ab  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China
E-mail: lina@sdnu.edu.cn, tangb@sdnu.edu.cn

b Laoshan Laboratory, Qingdao, P. R. China

Abstract

A nanomedicine was developed using a Cu-based metal–organic framework (MOF) to co-deliver Cu(I) and prodrugs for targeted biorthogonally catalyzed chemotherapy and chemodynamic therapy of hepatocellular carcinoma.

Graphical abstract: Cu-MOF-based targeted nanomedicine utilizing biorthogonally catalyzed chemotherapy and chemodynamic therapy with spatiotemporal orchestration to treat hepatocellular carcinoma

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Article information

DOI
https://doi.org/10.1039/D4CC05890A
Article type
Communication
Submitted
04 Nov 2024
Accepted
13 Dec 2024
First published
19 Dec 2024

Chem. Commun., 2025,61, 1415-1418

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Cu-MOF-based targeted nanomedicine utilizing biorthogonally catalyzed chemotherapy and chemodynamic therapy with spatiotemporal orchestration to treat hepatocellular carcinoma

X. Wan, Y. Zhang, H. Zhang, W. Pan, X. Qiao, N. Li and B. Tang, Chem. Commun., 2025, 61, 1415 DOI: 10.1039/D4CC05890A

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