A covalent organic framework-based nanoreactor for enhanced chemodynamic therapy through cascaded Fenton-like reactions and nitric oxide delivery

Abstract

Herein, we report a nanoscale composite COF material loaded with copper peroxide (CuO₂) and nitric oxide (NO) prodrug via a stepwise post-synthetic modification. The obtained CuO₂@COF-SNO can undergo a cascade reaction in the tumor microenvironment to generate reactive oxygen and nitrogen species (ROS/RNS) to enhance chemodynamic therapy of the tumor.