To develop a process for the synthesis of an enal acetate, the so called C5-acetate that is important in the industrial preparation of vitamin A, we show here that Co(II)-based hydrogen atom transfer catalysts under H2 promote such isomerizations in high yield with low catalyst loading (0.1 mol%). D-labelling studies suggest the enal isomerization process and catalyst activation by H2 to be reversible.
Q. Qiqige, E. Richmond, R. Paciello, M. Schelwies and R. J. Lundgren, Chem. Commun., 2025, 61, 6174 DOI: 10.1039/D4CC06075J
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