Issue 15, 2025
From the journal:

Chemical Communications

Precise detection of NSE and ProGRP with nanoprobes for early diagnosis of small cell lung cancer†

Keyi Wang,‡a   Zixuan Chang,‡a   Yingjie Li,a   Yinian Wang,a   Yue Tang,*b   Xiaonan Gao ORCID logo *a  and  Bo Tang ORCID logo *ac  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China
E-mail: Tangbo@sdnu.edu.cn, gaox@sdnu.edu.cn

b Department of Emergency Medicine, Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, P. R. China
E-mail: yuetang0531@hotmail.com

c Laoshan Laboratory, 168Wenhai Middle Rd, Aoshanwei Jimo, Qingdao 266237, P. R. China

Abstract

A DNA strand-based fluorescent probe was developed for the direct simultaneous detection of small cell lung cancers’ tumor markers NSE and ProGRP. The probe offers stability, simplicity, and rapid response, making it highly promising for application in clinical serum samples’ diagnosis.

Graphical abstract: Precise detection of NSE and ProGRP with nanoprobes for early diagnosis of small cell lung cancer

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Article information

DOI
https://doi.org/10.1039/D4CC06230B
Article type
Communication
Submitted
23 Nov 2024
Accepted
23 Jan 2025
First published
27 Jan 2025

Chem. Commun., 2025,61, 3179-3182

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Precise detection of NSE and ProGRP with nanoprobes for early diagnosis of small cell lung cancer

K. Wang, Z. Chang, Y. Li, Y. Wang, Y. Tang, X. Gao and B. Tang, Chem. Commun., 2025, 61, 3179 DOI: 10.1039/D4CC06230B

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