Hypoxia-responsive bilirubin supramolecular nanoprodrugs for targeted photothermal-chemotherapy

Yu Xie; Liangshun Zheng; Tingting Chen; Yue Ding

doi:10.1039/D4CC06433J

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Hypoxia-responsive bilirubin supramolecular nanoprodrugs for targeted photothermal-chemotherapy†

Yu Xie,^a Liangshun Zheng,^a Tingting Chen*^a and Yue Ding

*^a

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* Corresponding authors

^a School of Chemistry and Chemical Engineering, Nantong University, Nantong, P. R. China
E-mail: yueding@ntu.edu.cn

Abstract

A bilirubin supramolecular nanoprodrug (SCBR/TPZ) with enhanced cellular uptake towards the HepG2 cell line was constructed based on host–guest recognition, which provided an innovative strategy to design a hypoxia-responsive BR supramolecular nanoprodrug for lactose-targeted photothermal-chemotherapy (PTT-CT) with a synergistic effect towards HepG2.

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Article information

DOI: https://doi.org/10.1039/D4CC06433J
Article type: Communication
Submitted: 05 Dec 2024
Accepted: 29 Jan 2025
First published: 29 Jan 2025

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Chem. Commun., 2025,61, 3512-3515

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Hypoxia-responsive bilirubin supramolecular nanoprodrugs for targeted photothermal-chemotherapy

Y. Xie, L. Zheng, T. Chen and Y. Ding, Chem. Commun., 2025, 61, 3512 DOI: 10.1039/D4CC06433J

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Chemical Communications

Hypoxia-responsive bilirubin supramolecular nanoprodrugs for targeted photothermal-chemotherapy†

Abstract

Supplementary files

Article information

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Hypoxia-responsive bilirubin supramolecular nanoprodrugs for targeted photothermal-chemotherapy

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