Issue 33, 2025
From the journal:

Chemical Communications

Stable dispersion and prolonged dissolution of hydrophilic pharmaceutical achieved by room-temperature atmospheric pressure atomic layer deposition†

Viet Phuong Cao, ORCID logo a   Kim-Hue Thi Dinh, ORCID logo a   Truong Duc Dinh,a   Phi Huu Bui,a   Tuan Hiep Tranb  and  Hao Van Bui ORCID logo *a  

* Corresponding authors

a Faculty of Materials Science and Engineering, Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam
E-mail: hao.buivan@phenikaa-uni.edu.vn

b Faculty of Pharmacy, Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam

Abstract

We demonstrate atomic layer deposition of SiO2 films on hydrophilic diclofenac sodium pharmaceutical powder under ambient conditions. We reveal that the SiO2 layer not only prolongs the dissolution but also enhances the surface zeta potential of the coated products, preventing sedimentation and enabling a highly stable dispersion in water.

Graphical abstract: Stable dispersion and prolonged dissolution of hydrophilic pharmaceutical achieved by room-temperature atmospheric pressure atomic layer deposition

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Article information

DOI
https://doi.org/10.1039/D4CC06707J
Article type
Communication
Submitted
24 Dec 2024
Accepted
20 Mar 2025
First published
20 Mar 2025

Chem. Commun., 2025,61, 6186-6189

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Stable dispersion and prolonged dissolution of hydrophilic pharmaceutical achieved by room-temperature atmospheric pressure atomic layer deposition

V. P. Cao, K. T. Dinh, T. D. Dinh, P. H. Bui, T. H. Tran and H. Van Bui, Chem. Commun., 2025, 61, 6186 DOI: 10.1039/D4CC06707J

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