Polarity-sensitive probes (PAS) were synthesized through the attachment of azetidine and sulfonyl substituents to the pyrene fluorescent core. The emission peaks and fluorescence lifetimes of these PAS probes exhibit high sensitivity to polarity, enabling the visualization of microenvironmental characteristics and dynamics across multiple organelles.
L. Yang, Y. Cao, X. Bu, F. Peng, Q. Ai and B. Gao, Chem. Commun., 2025, 61, 3187 DOI: 10.1039/D5CC00097A
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