Synthesis of 2-glycosyl-quinazolines and 5-glycosyl-pyrazolo[1,2-a]cinnolines by Cp*Ir(iii)-catalyzed C–H activation/cyclization

Abstract

A novel strategy for the synthesis of 2-glycosyl-quinazolines and 5-glycosyl-pyrazolo[1,2-a]cinnolines has been established through an Ir-catalyzed C–H activation/annulation process. This approach features mild reaction conditions, exhibits good tolerance to diverse functional groups, and facilitates the stereoselective construction of heterocyclic C-glycosides. Significantly, this method is amenable to the late-stage modification of structurally intricate natural products, thus holding great potential in the field of organic synthesis and pharmaceutical chemistry.