Issue 32, 2025
From the journal:

Chemical Communications

Phosphine-mediated [2+3]/[2+3] domino annulation reaction: access to cyclopentane[3,4]pyrrolo[1,2-a]indoles†

Yannan Zhu, ORCID logo a   Nan He,a   Yumeng Li,a   Yuxuan Zhua  and  Gang Qi*a  

* Corresponding authors

a Faculty of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng 224051, China
E-mail: 15022522775@163.com

Abstract

A phosphine-mediated [2+3]/[2+3] domino annulation reaction between indole-derived enones and Morita–Baylis–Hillman (MBH) carbonates was discovered, delivering a series of cyclopentane[3,4]pyrrolo[1,2-a]indoles with up to 87% yield and >20 : 1 dr.

Graphical abstract: Phosphine-mediated [2+3]/[2+3] domino annulation reaction: access to cyclopentane[3,4]pyrrolo[1,2-a]indoles

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Article information

DOI
https://doi.org/10.1039/D5CC00618J
Article type
Communication
Submitted
04 Feb 2025
Accepted
06 Mar 2025
First published
15 Mar 2025

Chem. Commun., 2025,61, 5994-5997

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Phosphine-mediated [2+3]/[2+3] domino annulation reaction: access to cyclopentane[3,4]pyrrolo[1,2-a]indoles

Y. Zhu, N. He, Y. Li, Y. Zhu and G. Qi, Chem. Commun., 2025, 61, 5994 DOI: 10.1039/D5CC00618J

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