Phosphine-mediated [2+3]/[2+3] domino annulation reaction: access to cyclopentane[3,4]pyrrolo[1,2-a]indoles†
Abstract
A phosphine-mediated [2+3]/[2+3] domino annulation reaction between indole-derived enones and Morita–Baylis–Hillman (MBH) carbonates was discovered, delivering a series of cyclopentane[3,4]pyrrolo[1,2-a]indoles with up to 87% yield and >20 : 1 dr.