[Cu(NHC)(OR)] (R = C(CF3)3) complexes for N–H and S–H bond activation and as pre-catalysts in the Chan–Evans–Lam reaction

Abstract

The synthesis, isolation, and full characterization of a series of NHC–copper perfluoro–alkoxide complexes are reported. Their exceptional stability resides with the steric hindrance of the nonafluoro-tert-butyl alkoxide moiety, which exhibits a strong electron withdrawing effect. These new Cu(I) complexes are synthons that can permit the activation of acidic N–H and S–H bonds. The well-defined [Cu(IPr)(OC(CF₃)₃)] was investigated as a pre-catalyst in the Chan–Evans–Lam reaction.