Mechanochemical fluorination of unactivated tertiary alkyl chlorides

Abstract

We present here a high-efficiency, eco-friendly method for synthesizing alkyl fluorides (15 min, 50–89% yields) through halogen exchange, utilizing simple and readily available alkyl halides as starting materials. This catalyst-free method employs AgF as the fluorine source, operates under ball milling conditions, demonstrates broad functional group compatibility, and has found application in the synthesis of key intermediates for the marketed drug ledipasvir.