Trapping in situ generated CF3-nitrile imines with maleimides under solvent-free mechanochemical conditions

Abstract

A series of trifluoromethylated pyrrolo[3,4-c]pyrazoles was obtained via mechanochemical (3 + 2)-cycloaddition of in situ generated trifluoroacetonitrile imines with maleimide and its N-aliphatic/aromatic analogues. The presented work demonstrated that the aforementioned 1,3-dipoles can be efficiently trapped with electron-deficient dipolarophiles under solvent-free ball-milling conditions.