Construction of 1-acryloyl-2-cyanoindoles: unveiling their potential in radical cascade cyclization

Abstract

To develop a novel skeleton for the construction of nitrogen-containing heterocycle compounds by radical cascade cyclization reactions, we designed and synthesized 1,n-enyne-type platform compounds i.e., 1-acryloyl-2-cyanoindole compounds. The synthesized compounds showed good potential in radical cascade reactions, which was demonstrated in the photocatalytic sulfonation/cyclization reaction to give sulfonated pyrrolidoindoledione in good yield.