Mo(CO)6-catalyzed reductive coupling reaction to synthesize benzimidazoquinazolinones and dihydroquinazolinoquinazolinones

Ran Zhao; Xinrui Huang; Xiaoru Meng; Yuhan Wang; Ruiyu Li; Xiangwei Meng; Caixia Xie

doi:10.1039/D4OB01629G

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Mo(CO)₆-catalyzed reductive coupling reaction to synthesize benzimidazoquinazolinones and dihydroquinazolinoquinazolinones†

Ran Zhao,^a Xinrui Huang,^a Xiaoru Meng,^a Yuhan Wang,^a Ruiyu Li,^a Xiangwei Meng*^b and Caixia Xie

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry and Chemical Engineering, Shandong University of Technology, 266 West Xincun Road, Zibo 255049, PR China
E-mail: xiecx@sdut.edu.cn

^b Department of Drug Clinical Trials, Zibo Central Hospital Affiliated to Binzhou Medical University, 54 Gongqingtuan Xi Road, Zibo 255036, PR China
E-mail: mxwzbszxyy@163.com

Abstract

A series of benzimidazoquinazolinone and dihydroquinazolinoquinazolinone derivatives were synthesized by deploying a method in which Mo(CO)₆ was used as both reductant and cyclization accelerator. The preliminary anti-cancer activities of the obtained products were measured and several compounds were revealed to exhibit anti-cancer activities.

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Article information

DOI: https://doi.org/10.1039/D4OB01629G
Article type: Communication
Submitted: 09 Oct 2024
Accepted: 02 Dec 2024
First published: 03 Dec 2024

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Org. Biomol. Chem., 2025,23, 1078-1083

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Mo(CO)₆-catalyzed reductive coupling reaction to synthesize benzimidazoquinazolinones and dihydroquinazolinoquinazolinones

R. Zhao, X. Huang, X. Meng, Y. Wang, R. Li, X. Meng and C. Xie, Org. Biomol. Chem., 2025, 23, 1078 DOI: 10.1039/D4OB01629G

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Organic & Biomolecular Chemistry