Catalyst-free coupling of peroxypyrroloindolenines with amines to afford stable peroxyindolenines

Abstract

Here we report a highly efficient method for coupling of peroxypyrroloindolenines with amines under catalyst-free conditions to obtain stable C2–N peroxyindolenines in high yields with remarkable functional group tolerance. Initial studies have shown that compound 13 exhibits potent inhibition of the B16/F10 cell line with an IC₅₀ value of 2.18 μM.