Issue 5, 2025, Issue in Progress
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RSC Advances

An optical coherence tomography study of a photoactive Pt(iv) prodrug in oesophageal tissue†

Huayun Shi, ORCID logo *abc   Muktesh Mohan, ORCID logo de   Kanwarpal Singh ORCID logo *def  and  Peter J. Sadler ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Warwick, Coventry, UK
E-mail: Huayun.Shi@xmu.edu.cn, p.j.sadler@warwick.ac.uk

b State Key Laboratory of Vaccines for Infectious Diseases, Center for Molecular Imaging and Translational Medicine, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China

c State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, Xiamen University, Xiamen, China

d Max-Planck-Institut für die Physik des Lichts, Staudtstraße 2, 91058 Erlangen, Germany
E-mail: kanwarpal.singh@mpl.mpg.de

e Max-Planck-Zentrum für Physik und Medizin, Kussmaulallee 2, 91054 Erlangen, Germany

f Department of Electrical and Computer Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, Canada

Abstract

Photoactive diazido Pt(IV) complexes display in vivo anticancer efficacy towards oesophageal tumours, a worldwide common cancer. Here we explore the use of optical coherence tomography (OCT) as a new method for detecting tissue penetration and damage produced by the photoactivatable anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] (FM190). Dehydration of the sample and a change in refractive index were observed for swine oesophageal tissue treated with FM190 and blue laser light (445 nm) using an OCT system. In contrast, tissues treated with FM190 or laser light alone showed no apparent damage.

Graphical abstract: An optical coherence tomography study of a photoactive Pt(iv) prodrug in oesophageal tissue

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Article information

DOI
https://doi.org/10.1039/D4RA08693G
Article type
Paper
Submitted
10 Dec 2024
Accepted
10 Jan 2025
First published
31 Jan 2025
This article is Open Access
Creative Commons BY license

RSC Adv., 2025,15, 3168-3171

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An optical coherence tomography study of a photoactive Pt(IV) prodrug in oesophageal tissue

H. Shi, M. Mohan, K. Singh and P. J. Sadler, RSC Adv., 2025, 15, 3168 DOI: 10.1039/D4RA08693G

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