Issue 7, 2004
From the journal:

Chemical Communications

Solvent-drop grinding: green polymorph control of cocrystallisation†

Andrew V. Trask,a   W. D. Samuel Motherwellb  and  William Jones*a  

* Corresponding authors

a Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: wj10@cam.ac.uk
Fax: 44 1223 336362
Tel: 44 1223 334468

b Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, UK

Abstract

By grinding with a minimal addition of a solvent of appropriate polarity, control over the polymorphic outcome of a novel cocrystallisation involving the model pharmaceutical compound caffeine may be achieved.

Graphical abstract: Solvent-drop grinding: green polymorph control of cocrystallisation

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Article information

DOI
https://doi.org/10.1039/B400978A
Article type
Communication
Submitted
21 Jan 2004
Accepted
20 Feb 2004
First published
05 Mar 2004

Chem. Commun., 2004, 890-891

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Solvent-drop grinding: green polymorph control of cocrystallisation

A. V. Trask, W. D. S. Motherwell and W. Jones, Chem. Commun., 2004, 890 DOI: 10.1039/B400978A

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