Issue 4, 2007
From the journal:

Chemical Communications

Alternative donor substrates for inverting and retaining glycosyltransferases†

Luke L. Lairson,a   Warren W. Wakarchukb  and  Stephen G. Withers*ac  

* Corresponding authors

a Department of Chemistry, University of British Columbia, Vancouver, British Columbia, Canada
E-mail: withers@chem.ubc.ca
Fax: (604) 822-8869
Tel: (604) 822-3402

b Institute of Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada
E-mail: warren.wakarchuk@nrc.ca

c Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

Abstract

By the use of glycosyl donors containing aromatic leaving groups linked with opposite anomeric configurations compared to those of the natural donor substrates, an inverting (Cst II) and a retaining (LgtC) glycosyltransferase were found to catalyse glycosylation reactions of natural acceptor substrates in the presence of the corresponding nucleotide.

Graphical abstract: Alternative donor substrates for inverting and retaining glycosyltransferases

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Article information

DOI
https://doi.org/10.1039/B614636H
Article type
Communication
Submitted
09 Oct 2006
Accepted
01 Nov 2006
First published
07 Nov 2006

Chem. Commun., 2007, 365-367

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Alternative donor substrates for inverting and retaining glycosyltransferases

L. L. Lairson, W. W. Wakarchuk and S. G. Withers, Chem. Commun., 2007, 365 DOI: 10.1039/B614636H

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