Issue 42, 2011

Brønsted acid-catalyzed enantioselective Friedländer condensations: achiral amine promoter plays crucial role in the stereocontrol

Abstract

A highly enantioselective Friedländer condensation has been established by using chiral Brønsted acids in combination with achiral amines to give quinolines in high yields (up to 99%) and with excellent enantioselectivities (up to 95%).

Graphical abstract: Brønsted acid-catalyzed enantioselective Friedländer condensations: achiral amine promoter plays crucial role in the stereocontrol

Supplementary files

Article information

Article type
Communication
Submitted
07 Aug 2011
Accepted
05 Sep 2011
First published
26 Sep 2011

Chem. Commun., 2011,47, 11683-11685

Brønsted acid-catalyzed enantioselective Friedländer condensations: achiral amine promoter plays crucial role in the stereocontrol

L. Ren, T. Lei and L. Gong, Chem. Commun., 2011, 47, 11683 DOI: 10.1039/C1CC14873G

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