Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

Muhammad Hanif; Alexey A. Nazarov; Anton Legin; Michael Groessl; Vladimir B. Arion; Michael A. Jakupec; Yury O. Tsybin; Paul J. Dyson; Bernhard K. Keppler; Christian G. Hartinger

doi:10.1039/C1CC14713G

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules†‡

Muhammad Hanif,^ab Alexey A. Nazarov,^c Anton Legin,^a Michael Groessl,^c Vladimir B. Arion,^a Michael A. Jakupec,^a Yury O. Tsybin,^c Paul J. Dyson,^c Bernhard K. Keppler^a and Christian G. Hartinger*^ad

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^a University of Vienna, Institute of Inorganic Chemistry, Waehringer Str. 42, A-1090 Vienna, Austria
E-mail: christian.hartinger@univie.ac.at
Fax: +43-1-4277-9526
Tel: +43-1-4277-52609

^b Department of Chemistry, COMSATS Institute of Information Technology Abbottabad Campus, University Road, Abbottabad-22060, Pakistan

^c Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland

^d The University of Auckland, School of Chemical Sciences, Private Bag 92019, Auckland 1142, New Zealand

Abstract

Ru^II(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour.

This article is part of the themed collection: Emerging Investigators 2012

Chemical Communications

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules†‡

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Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

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