Issue 78, 2012
From the journal:

Chemical Communications

Dehydration from conserved stem regions is fundamental for ligand-dependent conformational transition of the adenine-specific riboswitch†‡

Vinit Kumar,a   Tamaki Endoh,a   Kentaro Murakamib  and  Naoki Sugimoto*ab  

* Corresponding authors

a Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamachi, Kobe 6500047, Japan

b Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamachi, Kobe 6500047, Japan
E-mail: sugimoto@konan-u.ac.jp
Fax: +81-78-303-1495
Tel: +81-78-303-1457

Abstract

Conformational dynamics and observed equilibrium constants for ligand binding of the adenine-specific riboswitch (add-A riboswitch) in the absence of Mg2+ and presence of various concentrations of poly-ethylene glycol having an average molecular weight of 200 indicated that 54.2 water molecules were released from P2 and P3 stem regions of the add-A riboswitch during conformational transition upon the binding of 2-aminopurine, an analog of the natural ligand adenine.

Graphical abstract: Dehydration from conserved stem regions is fundamental for ligand-dependent conformational transition of the adenine-specific riboswitch

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Article information

DOI
https://doi.org/10.1039/C2CC34506D
Article type
Communication
Submitted
23 Jun 2012
Accepted
19 Jul 2012
First published
19 Jul 2012

Chem. Commun., 2012,48, 9684-9686

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Dehydration from conserved stem regions is fundamental for ligand-dependent conformational transition of the adenine-specific riboswitch

V. Kumar, T. Endoh, K. Murakami and N. Sugimoto, Chem. Commun., 2012, 48, 9684 DOI: 10.1039/C2CC34506D

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