Issue 16, 2013
From the journal:

Chemical Communications

Pd(ii)-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C–H bond activation†

Jihye Park,a   Minyoung Kim,a   Satyasheel Sharma,a   Eonjeong Park,a   Aejin Kim,a   Sang Hwi Lee,a   Jong Hwan Kwak,a   Young Hoon Junga  and  In Su Kim*a  

* Corresponding authors

a School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea
E-mail: insukim@skku.edu
Fax: +82 31 292 8800
Tel: +82 31 290 7788

Abstract

A palladium-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C–H bond activation is described. This protocol provides efficient access to a range of ortho-acyl phenylacetamides, which can be easily converted to 3-isochromanone derivatives.

Graphical abstract: Pd(ii)-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C–H bond activation

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Article information

DOI
https://doi.org/10.1039/C3CC38764J
Article type
Communication
Submitted
06 Dec 2012
Accepted
07 Jan 2013
First published
08 Jan 2013

Chem. Commun., 2013,49, 1654-1656

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Pd(II)-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C–H bond activation

J. Park, M. Kim, S. Sharma, E. Park, A. Kim, S. H. Lee, J. H. Kwak, Y. H. Jung and I. S. Kim, Chem. Commun., 2013, 49, 1654 DOI: 10.1039/C3CC38764J

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