Issue 54, 2013
From the journal:

Chemical Communications

Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin–globotriose hybrids†

Atsushi Okochi,a   Shuho Tanimoto,a   Daisuke Takahashia  and  Kazunobu Toshima*a  

* Corresponding authors

a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan
E-mail: toshima@applc.keio.ac.jp
Fax: +81 45-566-1576

Abstract

Designed and synthesized porphyrin–globotriose hybrids effectively degraded verotoxin-1, which causes severe bloody diarrhoea and fetal hemolytic uremic syndrome (HUS). Degradation was achieved using long-wavelength UV or visible light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrids neutralized the cytotoxicity of verotoxin upon photo-irradiation.

Graphical abstract: Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin–globotriose hybrids

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Article information

DOI
https://doi.org/10.1039/C3CC42957A
Article type
Communication
Submitted
22 Apr 2013
Accepted
15 May 2013
First published
17 May 2013

Chem. Commun., 2013,49, 6027-6029

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Target-selective photo-degradation of verotoxin-1 and reduction of its cytotoxicity to Vero cells using porphyrin–globotriose hybrids

A. Okochi, S. Tanimoto, D. Takahashi and K. Toshima, Chem. Commun., 2013, 49, 6027 DOI: 10.1039/C3CC42957A

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