Issue 92, 2013
From the journal:

Chemical Communications

Expanding the scope of oxime ligation: facile synthesis of large cyclopeptide-based glycodendrimers†

Baptiste Thomas,a   Nathalie Berthet,a   Julian Garcia,a   Pascal Dumya  and  Olivier Renaudet*ab  

* Corresponding authors

a Département de Chimie Moléculaire, UMR-CNRS 5250 & ICMG FR 2607, Université Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France
E-mail: olivier.renaudet@ujf-grenoble.fr
Fax: +33 456-520-805

b Institut Universitaire de France, 103 boulevard Saint-Michel, 75005 Paris, France

Abstract

A new series of 64-valent glycodendrimers was prepared in excellent yield and purity using a divergent and iterative strategy based on oxime ligation. Enzyme-linked lectin assays revealed the first nanomolar inhibitor for the fucose-specific lectin isolated from Ulex europaeus.

Graphical abstract: Expanding the scope of oxime ligation: facile synthesis of large cyclopeptide-based glycodendrimers

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC45368E
Article type
Communication
Submitted
16 Jul 2013
Accepted
29 Sep 2013
First published
30 Sep 2013

Chem. Commun., 2013,49, 10796-10798

Permissions

Request permissions

Expanding the scope of oxime ligation: facile synthesis of large cyclopeptide-based glycodendrimers

B. Thomas, N. Berthet, J. Garcia, P. Dumy and O. Renaudet, Chem. Commun., 2013, 49, 10796 DOI: 10.1039/C3CC45368E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements