Issue 2, 2013
From the journal:

Green Chemistry

Direct aerobic oxidation of 2-benzylpyridines in a gas–liquid continuous-flow regime using propylene carbonate as a solvent†

Bartholomäus Piebera  and  C. Oliver Kappe*a  

* Corresponding authors

a Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010 Graz, Austria
E-mail: oliver.kappe@uni-graz.at
Fax: +43 316 3809840
Tel: +43 316 3805352

Abstract

The use of high-temperature/pressure gas–liquid continuous flow conditions dramatically enhances the iron-catalyzed aerobic oxidation of 2-benzylpyridines to their corresponding ketones. Pressurized air serves as a readily available oxygen source and propylene carbonate as a green solvent in this radically intensified preparation of synthetically valuable 2-aroylpyridines.

Graphical abstract: Direct aerobic oxidation of 2-benzylpyridines in a gas–liquid continuous-flow regime using propylene carbonate as a solvent

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Article information

DOI
https://doi.org/10.1039/C2GC36896J
Article type
Communication
Submitted
27 Nov 2012
Accepted
17 Dec 2012
First published
17 Dec 2012

Green Chem., 2013,15, 320-324

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Direct aerobic oxidation of 2-benzylpyridines in a gas–liquid continuous-flow regime using propylene carbonate as a solvent

B. Pieber and C. O. Kappe, Green Chem., 2013, 15, 320 DOI: 10.1039/C2GC36896J

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