Issue 56, 2014
From the journal:

Chemical Communications

A prospective antibacterial for drug-resistant pathogens: a dual warhead amphiphile designed to track interactions and kill pathogenic bacteria by membrane damage and cellular DNA cleavage†

Durairaj Thiyagarajan,a   Sudeep Goswami,a   Chirantan Kar,b   Gopal Das*b  and  Aiyagari Ramesh*a  

* Corresponding authors

a Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, India
E-mail: aramesh@iitg.ernet.in
Fax: +91 361 2582249
Tel: +91 361 2582205

b Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India
E-mail: gdas@iitg.ernet.in
Fax: +91 361 2582349
Tel: +91 361 2582313

Abstract

A rationally designed bactericidal amphiphile acts on compelling targets and has the potential to disarm resistance development in pathogenic bacteria.

Graphical abstract: A prospective antibacterial for drug-resistant pathogens: a dual warhead amphiphile designed to track interactions and kill pathogenic bacteria by membrane damage and cellular DNA cleavage

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Article information

DOI
https://doi.org/10.1039/C4CC02354D
Article type
Communication
Submitted
30 Mar 2014
Accepted
16 May 2014
First published
16 May 2014

Chem. Commun., 2014,50, 7434-7436

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A prospective antibacterial for drug-resistant pathogens: a dual warhead amphiphile designed to track interactions and kill pathogenic bacteria by membrane damage and cellular DNA cleavage

D. Thiyagarajan, S. Goswami, C. Kar, G. Das and A. Ramesh, Chem. Commun., 2014, 50, 7434 DOI: 10.1039/C4CC02354D

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