Issue 31, 2014

Rapid and facile solvent-free mechanosynthesis in a cell lysis mill: preparation and mechanochemical complexation of aminobenzoquinones

Abstract

A cell lysis mill, typically used for the breakdown of biological structures in microbiological and biochemical studies, was used as a tool for rapid, solvent-free and general synthesis of short- and long-chain substituted zwitterionic meta- and para-aminobenzoquinones, never previously prepared under solvent-free conditions. Rapid agitation and self-heating in the lysis mill enabled thermally-demanding reactions without external solvent, providing yields comparable to those obtained by conventional solution chemistry, ball milling and melt chemistry. The lysis mill is also suitable for coordination-based reactions, demonstrated by the mechanosynthesis of a mononuclear Ni(II) meta-benzoquinonemonoimine complex.

Graphical abstract: Rapid and facile solvent-free mechanosynthesis in a cell lysis mill: preparation and mechanochemical complexation of aminobenzoquinones

Supplementary files

Article information

Article type
Communication
Submitted
15 Feb 2014
Accepted
12 Jun 2014
First published
13 Jun 2014

CrystEngComm, 2014,16, 7180-7185

Rapid and facile solvent-free mechanosynthesis in a cell lysis mill: preparation and mechanochemical complexation of aminobenzoquinones

Y. Fang, N. Salamé, S. Woo, D. S. Bohle, T. Friščić and L. A. Cuccia, CrystEngComm, 2014, 16, 7180 DOI: 10.1039/C4CE00328D

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