Tunable coverage of immobilized biomolecules for biofunctional interface design

Jyun-Ting Wu; Ting-Pi Sun; Chao-Wei Huang; Chiao-Tzu Su; Chih-Yu Wu; Shu-Yun Yeh; Deng-Kai Yang; Lin-Chi Chen; Shih-Torng Ding; Hsien-Yeh Chen

doi:10.1039/C5BM00127G

Tunable coverage of immobilized biomolecules for biofunctional interface design†

Jyun-Ting Wu,‡^a Ting-Pi Sun,‡^a Chao-Wei Huang,‡^b Chiao-Tzu Su,‡^ac Chih-Yu Wu,^a Shu-Yun Yeh,^a Deng-Kai Yang,^d Lin-Chi Chen,^d Shih-Torng Ding^b and Hsien-Yeh Chen*^a

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* Corresponding authors

^a Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan
E-mail: hsychen@ntu.edu.tw

^b Department of Animal Science and Technology, National Taiwan University, Taipei 10617, Taiwan

^c Aeon Biotherapeutics Corp., Taipei 11494, Taiwan

^d Department of Bio-Industrial Mechatronics Engineering, National Taiwan University, Taipei 10617, Taiwan

Abstract

The controlled coverage of immobilized biomolecules is introduced, illustrating a concept for designing biomaterial surfaces such that the extent of manipulation employed to elicit biological responses is controlled according to density changes in the underlying chemical motifs and the density of immobilized biomolecules.

Biomaterials Science

Tunable coverage of immobilized biomolecules for biofunctional interface design†

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Tunable coverage of immobilized biomolecules for biofunctional interface design

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