Issue 2, 2015

Pd(ii)-catalyzed C–H arylation of aryl and benzyl Weinreb amides

Abstract

The first example of palladium-catalyzed ortho-C–H arylation of aryl and benzyl Weinreb amides was developed, in which HOTf was used as a key promoter. This method exhibits good functional group tolerance, a broad substrate scope of both Weinreb amides and aryl iodides, high mono-selectivity and mild reaction conditions.

Graphical abstract: Pd(ii)-catalyzed C–H arylation of aryl and benzyl Weinreb amides

Supplementary files

Article information

Article type
Communication
Submitted
25 Sep 2014
Accepted
24 Oct 2014
First published
24 Oct 2014

Org. Biomol. Chem., 2015,13, 353-356

Author version available

Pd(II)-catalyzed C–H arylation of aryl and benzyl Weinreb amides

Y. Wang, K. Zhou, Q. Lan and X. Wang, Org. Biomol. Chem., 2015, 13, 353 DOI: 10.1039/C4OB02039A

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