A new chemical derivatisation method to functionalise peptide and protein bound 3-nitrotyrosine residues is described. By transforming 3-nitrotyrosine to 3-azidotyrosine, the method enables ‘click chemistry’-based labelling of the 3-nitrotyrosine residues and provides new opportunities for the study of this post-translational modification in biological samples.
J. Y. Ng and J. W. H. Wong, Org. Biomol. Chem., 2015, 13, 374 DOI: 10.1039/C4OB02133A
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