An efficient annulation of vinyl azides with activated imines has been developed for the synthesis of poly-functionalized imidazole derivatives. This reaction includes thermal decomposition of vinyl azides to 2H-azirines, nucleophilic attack of 2H-azirines with activated imines and subsequent cyclization to desired imidazoles.
J. Luo, W. Chen, J. Shao, X. Liu, K. Shu, P. Tang and Y. Yu, RSC Adv., 2015, 5, 55808 DOI: 10.1039/C5RA07320K
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