Internal polymer scaffolding in lipid-coated microbubbles for control of inertial cavitation in ultrasound theranostics

Abstract

A lipid–polymer composite structure was developed for tuning of inertial cavitation activity of microbubbles under ultrasound exposure. The incorporation of a thin layer of polymer networks inside the lipid monolayer resulted in marked reduction in the inertial cavitation dose. This strategy has the potential to increase the safety of ultrasound theranostic applications assisted by microbubble cavitation.