Water-soluble poly(2,7-dibenzosilole) as an ultra-bright fluorescent label for antibody-based flow cytometry

Xin Wang; Yi-Zhen Hu; Aimei Chen; Yexin Wu; Robert Aggeler; Quentin Low; Hee Chol Kang; Kyle R. Gee

doi:10.1039/C5CC10347A

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Water-soluble poly(2,7-dibenzosilole) as an ultra-bright fluorescent label for antibody-based flow cytometry†‡

Xin Wang,^a Yi-Zhen Hu,^a Aimei Chen,^a Yexin Wu,^a Robert Aggeler,^a Quentin Low,^a Hee Chol Kang^a and Kyle R. Gee*^a

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* Corresponding authors

^a Biosciences Division, Thermo Fisher Scientific Inc. 29851 Willow Creek Rd., Eugene, OR, USA
E-mail: Kyle.Gee@thermofisher.com
Tel: +1-541-335-0366

Abstract

A series of novel water-soluble PEGylated dibenzosilole-based conjugated polymers were prepared as ultra-bright fluorescent labels for biomolecules. Due to their superior solubility and brightness, antibody conjugates labeled with functionalized polymers showed significantly enhanced signal and sensitivity relative to traditional fluorophores in functional flow cytometry applications.

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Article information

DOI: https://doi.org/10.1039/C5CC10347A
Article type: Communication
Submitted: 16 Dec 2015
Accepted: 12 Feb 2016
First published: 12 Feb 2016

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Chem. Commun., 2016,52, 4022-4024

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Water-soluble poly(2,7-dibenzosilole) as an ultra-bright fluorescent label for antibody-based flow cytometry

X. Wang, Y. Hu, A. Chen, Y. Wu, R. Aggeler, Q. Low, H. C. Kang and K. R. Gee, Chem. Commun., 2016, 52, 4022 DOI: 10.1039/C5CC10347A

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Chemical Communications

Water-soluble poly(2,7-dibenzosilole) as an ultra-bright fluorescent label for antibody-based flow cytometry†‡

Abstract

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Water-soluble poly(2,7-dibenzosilole) as an ultra-bright fluorescent label for antibody-based flow cytometry

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