The unusual phenomenon of the formation of the kinetic form as against the thermodynamic form upon slow cooling of boiling aqueous solution in the case of diuretic drug acetazolamide is rationalized in terms of “hybridization induced polymorphism” based on extensive experimental and theoretical investigations.
S. Sarkar, M. S. Pavan, S. Cherukuvada and T. N. Guru Row, Chem. Commun., 2016, 52, 5820 DOI: 10.1039/C6CC01612J
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