Issue 66, 2016
From the journal:

Chemical Communications

Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl2(NH3)2]†

Erin Wachter,‡a   Ana Zamora,‡b   David K. Heidary,a   José Ruizb  and  Edith C. Glazer*a  

* Corresponding authors

a Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
E-mail: ec.glazer@uky.edu
Fax: +1-859-323-1069
Tel: +1-859-257-2198

b Departamento de Química Inorgánica and Regional Campus of International Excellence “Campus Mare Nostrum”, Universidad de Murcia, and Institute for Bio-Health Research of Murcia (IMIB-Arrixaca), E-30771 Murcia, Spain

Abstract

Two thermally activated ruthenium(II) polypyridyl complexes, cis-Ru(bpy)2Cl2 and trans-Ru(qpy)Cl2 were investigated to determine the impact of the geometric arrangement of the exchangable ligands on the potential of the compounds to act as chemotherapeutics. In contrast to the geometry requirements for cisplatin, trans-Ru(qpy)Cl2 was 7.1–9.5× more cytotoxic than cis-Ru(bpy)2Cl2. This discovery could open up a new area of metal-based chemotherapeutic research.

Graphical abstract: Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(ii) polypyridyl complexes from cis/trans-[PtCl2(NH3)2]

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Article information

DOI
https://doi.org/10.1039/C6CC04813G
Article type
Communication
Submitted
08 Jun 2016
Accepted
21 Jun 2016
First published
23 Jun 2016

Chem. Commun., 2016,52, 10121-10124

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Geometry matters: inverse cytotoxic relationship for cis/trans-Ru(II) polypyridyl complexes from cis/trans-[PtCl2(NH3)2]

E. Wachter, A. Zamora, D. K. Heidary, J. Ruiz and E. C. Glazer, Chem. Commun., 2016, 52, 10121 DOI: 10.1039/C6CC04813G

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