Issue 8, 2017
From the journal:

Biomaterials Science

Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer†

Bing Feng,‡ab   Fangyuan Zhou,‡a   Wenchao Lu,bc   Dangge Wang,ab   Tingting Wang,ab   Cheng Luo,c   Hao Wang, ORCID logo d   Yaping Lia  and  Haijun Yu ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
E-mail: hjyu@simm.ac.cn
Fax: +86-21-2023-1979
Tel: +86-21-2023-1979

b University of Chinese Academy of Sciences, Beijing 100049, China

c Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

d National Center for Nanoscience and Technology, Beijing 100190, China

Abstract

A phospholipid-mimic oxaliplatin prodrug (Oxalipid) was synthesized, which could self-assemble into a liposomal nanostructure with a drug loading ratio as high as 27 wt%. Compared to free oxaliplatin, the resulting Oxalipid liposome displayed elongated blood circulation, increased tumor accumulation and improved anticancer efficacy against the metastatic triple negative breast cancer (TNBC).

Graphical abstract: Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer

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Article information

DOI
https://doi.org/10.1039/C7BM00058H
Article type
Communication
Submitted
19 Jan 2017
Accepted
31 Mar 2017
First published
31 Mar 2017

Biomater. Sci., 2017,5, 1522-1525

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Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer

B. Feng, F. Zhou, W. Lu, D. Wang, T. Wang, C. Luo, H. Wang, Y. Li and H. Yu, Biomater. Sci., 2017, 5, 1522 DOI: 10.1039/C7BM00058H

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