Issue 8, 2017
From the journal:

Biomaterials Science

Glycocalyx scaffolding with synthetic nanoscale glycomaterials†

Mia L. Huang,a   Sean C. Purcell,a   Stephen Verespy III,a   Yinan Wanga  and  Kamil Godula ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, USA
E-mail: kgodula@ucsd.edu

Abstract

We report a method for programming complexity into the glycocalyx of live cells. Via a combination of glycomaterial synthesis and membrane remodeling, we have engineered cells to display native-like, mixed sialoglycan populations, while confining the activity of each glycan into a specific nanoscale presentation.

Graphical abstract: Glycocalyx scaffolding with synthetic nanoscale glycomaterials

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Article information

DOI
https://doi.org/10.1039/C7BM00289K
Article type
Communication
Submitted
31 Mar 2017
Accepted
06 Jun 2017
First published
08 Jun 2017

Biomater. Sci., 2017,5, 1537-1540

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Glycocalyx scaffolding with synthetic nanoscale glycomaterials

M. L. Huang, S. C. Purcell, S. Verespy III, Y. Wang and K. Godula, Biomater. Sci., 2017, 5, 1537 DOI: 10.1039/C7BM00289K

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