Issue 41, 2017

Photo-cleavable analog of BAPTA for the fast and efficient release of Ca2+

Abstract

A new photocleavable analog of BAPTA chelating ligand has a high affinity towards Ca2+ ions (K = 2.5 × 106 M−1). The use of photolabile 3-(hydroxymethyl)-2-naphthol core in the design of photo-BAPTA allows for the efficient (Φ = 0. 63) and very fast (τ < 12 μs) release of Ca2+ ions upon 300 or 350 nm irradiation.

Graphical abstract: Photo-cleavable analog of BAPTA for the fast and efficient release of Ca2+

Supplementary files

Article information

Article type
Communication
Submitted
17 Mar 2017
Accepted
03 Apr 2017
First published
05 Apr 2017

Chem. Commun., 2017,53, 5598-5601

Photo-cleavable analog of BAPTA for the fast and efficient release of Ca2+

M. V. Sutton, M. McKinley, R. Kulasekharan and V. V. Popik, Chem. Commun., 2017, 53, 5598 DOI: 10.1039/C7CC02056B

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