Xing Li*,
Xiaolei Gong,
Zhipeng Li,
Honghong Chang,
Wenchao Gao and
Wenlong Wei*
Department of Chemistry and Chemical Engineering, Taiyuan University of Technology, 79 West Yingze Street, Taiyuan 030024, People's Republic of China. E-mail: lixing@tyut.edu.cn; weiwenlong@tyut.edu.cn
First published on 12th January 2017
The ligand- and copper-free Sonogashira reaction of (Het)aryl halides (Br and Cl) with various terminal alkynes and the Heck coupling of (Het)aryl halides (Br and Cl) with a series of olefins, catalyzed by palladium nanoparticles supported on newly generated Al(OH)3, were developed. The catalyst can be readily recovered and reused 6 times without significant loss of activity and palladium leaching.
Palladium-catalyzed cross-coupling reactions have become one of the most prominent and powerful methods for the formation of carbon–carbon bonds.3 Among them, the Sonogashira4 and Heck5 reactions have been found useful in the synthesis of a variety of target compounds with applications ranging from natural products and pharmaceuticals to organic functional materials. Significant progress has been achieved by using palladium salts6,7 or homogeneous palladium complexes8,9 as catalysts in the absence of copper co-catalysts. However, these two reactions still suffer from some limitations about the environmental and economical sustainability. In most cases, catalysts failed to be recycled and reused, and phosphorus ligands were also employed. To address these challenges, intense research efforts have been devoted to find suitable heterogeneous Pd catalysts of broad scope, capable of allowing the elimination of copper and phosphorus ligands, as well as affording recovery and reuse of costly palladium catalyst. Although several notable examples of truly green conditions for the Sonogashira10 and Heck11 reactions were reported, the substrate scope is still limited and successful examples for heteroaryl halides remain rare because the corresponding reactions of heteroaryl bromides proved to be more challenging.12,13 From the viewpoint of synthetic cost, developing a generally applicable catalytic system with broader substrate scope has received considerable attention and is highly desirable. Herein, we will report the application of such a palladium nanoparticles catalyst14 supported on Al(OH)3 which was in situ formed (see Scheme 1) in ligand- and copper-free Sonogashira and Heck cross-coupling reactions of (Het)aryl bromides and chlorides. The catalyst has exhibited obviously higher catalytic activity than that prepared by co-precipitation, which demonstrate that the preparation methods of the catalyst exerted an important impact.14d
We first investigated the Sonogashira reaction between 4-methoxybromobenzene (1o) with phenylacetylene (2a) to optimize reaction conditions (Table 1). Screening of common solvents showed that DMSO was the best choice over DMF, and H2O (entry 2 vs. 1 and 3). Bases have a strong effect on the yield, and NaOAc was the best among the bases screened, including K2CO3, K3PO4 and KOAc (entries 7 vs. 2, 4, 5). The reaction did not give 3o at all when KOH was used (entry 6). It was noteworthy that the addition of TBAB improved the result further, providing 3o in 91% yield (entry 8).
Entry | Solvent | Base | Yieldb (%) |
---|---|---|---|
a Reactions were performed with 4-methoxybromobenzene (0.2 mmol) under N2 atmosphere at 120 °C for 40 h.b Isolated yield.c N.D. = Not detected.d Reaction conditions: 4-methoxybromobenzene (0.2 mmol), phenylacetylene (1.5 equiv.), Pd catalyst 1 (8.8 mg, 0.2 mol%), NaOAc (1.5 equiv.), TBAB (0.5 equiv.), DMSO (1.0 mL), N2, 120 °C. | |||
1 | DMF | K2CO3 | 21 |
2 | DMSO | K2CO3 | 36 |
3 | H2O | K2CO3 | Trace |
4 | DMSO | K3PO4 | 13 |
5 | DMSO | KOAc | 37 |
6 | DMSO | KOH | N.D.c |
7 | DMSO | NaOAc | 62 |
8d | DMSO | NaOAc | 91 |
With the optimized protocol in hand, the scope of this catalytic system was next explored. Aryl halides in reaction with 2a were investigated first (Table 2). The reaction worked very well for a range of aryl bromides with various substituents at the phenyl ring, and the products were isolated in good to excellent yields. Aryl bromides with electron-withdrawing substituents at the phenyl ring afforded the desired 1,3-diynes in high yields (3b–3j), whereas aryl bromides bearing electron-donating substituents provided the desired 1,3-diynes in 81–91% yields (3k–3o). The experimental results indicated that α-, and β-bromide substituted naphthalene afforded similarly good yields (3p and 3q). Sterically hindered 1-bromo-3,4-difluorobenzene was also suitable for this transformation (3r). Moreover, the arene ring is not limited to benzene rings. Heteroaryl bromides derived from pyridines, thiophenes, quinolines, and pyrimidines could be converted to the corresponding cross-coupled products in modest to high yields (3s–3zb). NO2-substituted aryl chlorides were also deemed to be suitable cross-coupling partners (3b–3d). Unfortunately, 1-chloronaphthalene and 4-methylchlorobenzene gave only 53% and 41% yields, respectively (3p and 3m).
Consequently, the scope of the arylacetylenes was examined in the coupling with bromobenzene. Phenylacetylene bearing electron-donating and electron-withdrawing groups in the benzene ring furnished the products in good to excellent yields, respectively (Table 3, 3e–3m, 3zc). The reactions of 4-ethynyltoluene and 1-ethynyl-4-fluorobenzene with 4-nitrobromobenzene were smoothly carried out to furnish the desired products (Table 3, 3zd and 3ze). In addition, 2-ethynylpyridine and 3-ethynylthiophene, heteroaryl alkynes, were also viable partners, providing 74% and 31% yields, respectively (Table 3, 3s and 3zf).
To test the effect of this nano-Pd catalyst in the Heck coupling reaction, the coupling of bromobenzene 1a and butyl acrylate 4a was chosen for initial study. Different solvents were explored in an effort to optimize the yield of 5a. As shown in Table 4, TBAB gave 5a in the highest yield and only poor to moderate yields were obtained with other solvents like dioxane, DMF, NMP, and acetonitrile (Table 4, entry 5 vs. 1–4). Among the bases evaluated, K3PO4 was found to be optimal. Lower yields were provided with K2CO3, TBAA, Et3N and NaOAc (Table 4, entry 5 vs. 6–9). Further optimization clearly indicated that lower catalyst loading and temperature resulted in bad results (Table 4, entries 10–11 vs. 5).
Entry | Solvent | Base | Cat. 1 (mol% Pd) | T (°C) | Yieldb (%) |
---|---|---|---|---|---|
a Reaction conditions: bromobenzene (0.2 mmol), butyl acrylate (0.26 mmol, 1.3 equiv.), catalyst 1, base (0.2 mmol), solvent, N2 for 19 h.b Isolated yield. | |||||
1 | DMF (0.5 mL) | K3PO4 | 0.1 | 130 | 78 |
2 | NMP (0.5 mL) | K3PO4 | 0.1 | 130 | 74 |
3 | CH3CN (0.5 mL) | K3PO4 | 0.1 | 130 | 61 |
4 | Dioxane (0.5 mL) | K3PO4 | 0.1 | 130 | Trace |
5 | TBAB (0.3 g) | K3PO4 | 0.1 | 130 | 99 |
6 | TBAB (0.3 g) | K2CO3 | 0.1 | 130 | 48 |
7 | TBAB (0.3 g) | TBAA | 0.1 | 130 | 86 |
8 | TBAB (0.3 g) | Et3N | 0.1 | 130 | 61 |
9 | TBAB (0.3 g) | NaOAc | 0.1 | 130 | 79 |
10 | TBAB (0.3 g) | K3PO4 | 0.07 | 130 | 82 |
11 | TBAB (0.3 g) | K3PO4 | 0.1 | 120 | 89 |
To demonstrate the generality of this nanoparticles pd catalyst 1, our attention was next focused on investigating the substrate scope for Heck cross-coupling using a variety of aryl halides.15 In all of our cases, both electron-rich and electron-poor groups and some heteroaryl rings substituted aryl bromides reacted with butyl acrylate to give the desired products in moderate to high yields, exhibiting a good efficiency (Table 5, 5a–5s). It was found that moderate to good yields could also be obtained when NO2- and Me-substituted chlorobenzenes were used as substrates with longer reaction time and more catalyst loading (Table 5, 5b–5d and 5i–5k). Furthermore, a series of functional groups, including Me-, F-, and diMe-substituted styrenes could smoothly couple with bromobenzene to provide good results (Table 6, 5t–5za).
a Reaction conditions: (hetero)aryl bromide (0.2 mmol), butyl acrylate (0.26 mmol), catalyst 1 (0.1 mol% Pd), K3PO4 (0.2 mmol), TBAB (0.3 g), N2, 130 °C.b Isolated yield.c Reaction conditions: aryl chloride (0.2 mmol), butyl acrylate (0.26 mmol), catalyst 1 (0.1 mol% Pd), K3PO4 (0.2 mmol), TBAB (0.3 g), DMF (0.2 mL), N2, 130 °C. |
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We further turned our attention to the recovery and reuse of the nano-Pd catalyst 1 through the Sonogashira reaction between 4-methoxybromobenzene (1o) with phenylacetylene (2a) and the results are shown in Table 7. The catalyst could be recovered through membrane filtration and reused in the next reaction. The experimental results showed that the catalytic activity and reaction yield did not obviously decrease after the sixth consecutive cycles. Moreover, the palladium leaching during the recovery process was not obviously observed which was determined by inductively coupled plasma atomic emission spectroscopy (ICP-AES) (Table 7, runs 1–6 vs. 0).
Run | Time (h) | Yieldb (%) | Pd contentc (wt%) |
---|---|---|---|
a Reaction conditions: 1o (1.0 equiv.), 2a (1.5 equiv.), Pd catalyst 1 (0.2 mol% Pd), NaOAc (1.5 equiv.), TBAB (0.5 equiv.), DMSO (1.0 mL), N2, 120 °C.b Isolated yield.c The Pd content of the recovered catalyst 1. | |||
0 | 40 | 91 | 0.48 |
1 | 40 | 91 | 0.48 |
2 | 41 | 90 | 0.47 |
3 | 42 | 90 | 0.46 |
4 | 42 | 90 | 0.46 |
5 | 43 | 90 | 0.46 |
6 | 45 | 89 | 0.45 |
In conclusion, we have developed efficient, practical and general copper-free Sonogashira and Heck cross-coupling reactions using a nanoparticles pd catalyst supported on in situ generated Al(OH)3. Broad substrate scope, high levels of functional group compatibility especially with heteraryl compounds, and modest to high yields of products are the notable features of the present reactions.
Footnote |
† Electronic supplementary information (ESI) available. See DOI: 10.1039/c6ra25416k |
This journal is © The Royal Society of Chemistry 2017 |