Zwitterion-coated ultrasmall iron oxide nanoparticles for enhanced T1-weighted magnetic resonance imaging applications

Dan Ma; Jingwen Chen; Yu Luo; Han Wang; Xiangyang Shi

doi:10.1039/C7TB01588G

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Zwitterion-coated ultrasmall iron oxide nanoparticles for enhanced T₁-weighted magnetic resonance imaging applications†

Dan Ma,‡^a Jingwen Chen,‡^b Yu Luo,^a Han Wang*^bc and Xiangyang Shi

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Author affiliations

* Corresponding authors

^a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, People's Republic of China
E-mail: xshi@dhu.edu.cn

^b Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, People's Republic of China
E-mail: 13564112852@163.com

^c National Engineering Research Center for Nanotechnology, Shanghai 200241, People's Republic of China

^d CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal

Abstract

We report a convenient strategy to prepare ultrasmall Fe₃O₄ nanoparticles (NPs) coated with zwitterion L-cysteine (Cys) for enhanced T₁-weighted magnetic resonance (MR) imaging applications. The formed Fe₃O₄–PEG–Cys NPs possess antifouling properties, good r₁ relaxivity, excellent cytocompatibility and hemocompatibility, and can be used as a contrast agent for enhanced blood pool and tumor MR imaging.

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Article information

DOI: https://doi.org/10.1039/C7TB01588G
Article type: Communication
Submitted: 11 Jun 2017
Accepted: 10 Aug 2017
First published: 10 Aug 2017

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J. Mater. Chem. B, 2017,5, 7267-7273

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Zwitterion-coated ultrasmall iron oxide nanoparticles for enhanced T₁-weighted magnetic resonance imaging applications

D. Ma, J. Chen, Y. Luo, H. Wang and X. Shi, J. Mater. Chem. B, 2017, 5, 7267 DOI: 10.1039/C7TB01588G

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Journal of Materials Chemistry B