Chiral amine-catalyzed asymmetric conjugate addition of aldehydes to α-phenylselenoenones as formal Z-allylating agents

Abstract

α-Selenoenones could be employed as Z-allyl precursors in the chiral amine-catalyzed asymmetric conjugate addition of aldehydes. The obtained formal allylation product, a Z-olefin having a sulfonate leaving group, was employed as a synthetically useful chiral alkylating agent.