Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner

Abstract

Serum amyloid A action in immune response and deposition in inflammation-linked amyloidosis involve SAA–lipid interactions. We show that SAA sequesters neutral and anionic phospholipids and their hydrolytic products to form nanoparticles, suggesting a synergy with phospholipase A₂. The lipid charge and shape affect SAA protection from proteolysis, aggregation and fibrillogenesis.