Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays

Akinobu Senoo; Satoru Nagatoishi; Anna Moberg; Linnea Nygren Babol; Tomoya Mitani; Takumi Tashima; Shota Kudo; Kouhei Tsumoto

doi:10.1039/C8CC01964A

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Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays†

Akinobu Senoo,^a Satoru Nagatoishi,

^abc Anna Moberg,^d Linnea Nygren Babol,^d Tomoya Mitani,^e Takumi Tashima,^a Shota Kudo^a and Kouhei Tsumoto

*^abc

Author affiliations

* Corresponding authors

^a Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

^b Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

^c Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

^d GE Healthcare Bio-sciences AB, Björkgatan 30, SE-751 84 Uppsala, Sweden

^e Life Science Division, GE Healthcare Japan, 3-25-1 Hyakunincho, Tokyo 169-0073, Japan
E-mail: tsumoto@bioeng.t.u-tokyo.ac.jp

Abstract

The inhibitor for the homophilic dimerization of P-cadherin was discovered by SPR-based screening using fragment compounds. Our SPR assays identified a specific P-cadherin binder, which was able to inhibit the cell adhesion of living CHO cells that expressed P-cadherin.

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Article information

DOI: https://doi.org/10.1039/C8CC01964A
Article type: Communication
Submitted: 12 Mar 2018
Accepted: 28 Apr 2018
First published: 09 May 2018

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Chem. Commun., 2018,54, 5350-5353

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Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays

A. Senoo, S. Nagatoishi, A. Moberg, L. N. Babol, T. Mitani, T. Tashima, S. Kudo and K. Tsumoto, Chem. Commun., 2018, 54, 5350 DOI: 10.1039/C8CC01964A

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Chemical Communications

Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays†

Abstract

Supplementary files

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Inhibition of homophilic dimerization and disruption of cell adhesion by P-cadherin-specific small molecules from SPR-based assays

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