A negatively-charged and nucleus-targeted DNA tetrahedron is rationally designed and used as a nanocarrier of positively-charged metal complexes. This tetrahedron speeds up the translocation of metal complexes into the cell nucleus, and inhibits the growth and invasion of glioma cells by triggering vascular mimicry-associated signaling pathways, thus achieving precise glioma treatment.
Y. Tian, Y. Huang, P. Gao and T. Chen, Chem. Commun., 2018, 54, 9394 DOI: 10.1039/C8CC04021D
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