Issue 82, 2018
From the journal:

Chemical Communications

Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials†

N. L. Fletcher, ORCID logo ab   Z. H. Houston, ORCID logo ab   J. D. Simpson, ORCID logo ab   R. N. Veedu ORCID logo cd  and  K. J. Thurecht ORCID logo *ab  

* Corresponding authors

a Centre for Advanced Imaging (CAI), Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD, Australia
E-mail: k.thurecht@uq.edu.au

b ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, Brisbane, QLD, Australia

c Centre for Comparative Genomics, Murdoch University, Perth, WA, Australia

d Perron Institute for Neurological and Translational Science, Perth, WA, Australia

Abstract

We report a novel multifunctional hyperbranched polymer based on polyethylene glycol (PEG) as a nanomedicine platform that facilitates longitudinal and quantitative 89Zr-PET imaging, enhancing knowledge of nanomaterial biodistribution and pharmacokinetics/pharmacodynamics both in vivo and ex vivo. Anti-VEGF-A DNA aptamer functionalization increased tumour accumulation by >2-fold in a breast cancer model.

Graphical abstract: Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials

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Article information

DOI
https://doi.org/10.1039/C8CC05831H
Article type
Communication
Submitted
18 Jul 2018
Accepted
28 Aug 2018
First published
05 Sep 2018

Chem. Commun., 2018,54, 11538-11541

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Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials

N. L. Fletcher, Z. H. Houston, J. D. Simpson, R. N. Veedu and K. J. Thurecht, Chem. Commun., 2018, 54, 11538 DOI: 10.1039/C8CC05831H

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