An unusual reactivity of nitrostyrenes in phosphorous acid was discovered, which permits the employment of these readily available synthons as 1,4-CCNO-dipole surrogates in a highly diastereoselective (4+1)-cycloaddition of indoles to afford 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form.
![Graphical abstract: Nitrostyrenes as 1,4-CCNO-dipoles: diastereoselective formal [4+1] cycloaddition of indoles](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C8CC07451H&imageInfo.ImageIdentifier.Year=2018)
A. V. Aksenov, N. A. Aksenov, D. A. Aksenov, V. F. Khamraev and M. Rubin, Chem. Commun., 2018, 54, 13260 DOI: 10.1039/C8CC07451H
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