Xiuling Chen*,
Siying Hu,
Rongxing Chen,
Jian Wang,
Minghu Wu,
Haibin Guo and
Shaofa Sun*
Hubei University Of Science and Technology, China
First published on 25th January 2018
An efficient Fe-catalyzed esterification of primary, secondary, and tertiary amides with various alcohols for the preparation of esters was performed. The esterification process was accomplished with FeCl3·6H2O, which is a stable, inexpensive, environmentally friendly catalyst with high functional group tolerance.
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We initially selected benzamide 1a and ethanol 2a as model substrates to screen the reaction conditions, and the results are summarized in Table 1. First, in the presence of FeCl2, ethyl benzoate 3a was afforded in 31% yield (Table 1, entry 1). Next, our catalyst-screening results showed that various iron complexes such as FeCl3, FeBr3, FeSO4·7H2O, FeCl3·6H2O, and Fe(NO3)3·9H2O could catalyze the reaction (Table 1, entries 2–6), and FeCl3·6H2O was the best catalyst for this reaction as ethyl benzoate 3a was afforded in 35% yield (Table 1, entry 6). Other metal complexes such as CuCl2, PdCl2, and NiCl2·6H2O did not improve the efficiency of this transformation (Table 1, entries 7–9). In the absence of an iron complex, this reaction could not work and the product was not detected (Table 1, entry 10). Next, in the presence of FeCl3·6H2O, the influence of additives on the reaction was investigated (Table 1, entries 11–18). Among the tested additives, the stronger bidentate ligands such as 1,10-phenanthroline or 2,2-bipyridine did not show any efficiency, while hydrochloric acid gave the best reactive activity as ethyl benzoate 3a was obtained in 91% yield (Table 1, entry 18). In general, H2SO4 or HNO3 was used as a catalyst for esterification; however, they did not efficiently promote the reaction under the present system (Table 1, entries 16–17). In the absence of FeCl3·6H2O, the product 3a was afforded in 35% yield (Table 1, entry 19). For the solvents investigated (Table 1, entries 20–23), n-hexane was the best choice (Table 1, entry 18).
Entry | Catalyst (20%) | Additive (40%) | Yieldb |
---|---|---|---|
a Reaction conditions: 1a (0.2 mmol), 2a (0.1 mL), catalyst (0.04 mmol, 20 mol%), H2SO4 (concentrated, 0.24 mmol), HNO3 (concentrated, 0.24 mmol), HCl (0.24 mmol, 36–38%), n-hexane (1.0 mL), 80 °C, 14 h.b GC yield using hexadecane as internal standard.c DMF was used as a solvent.d 1,4-Dioxane was used as solvent.e Toluene was used as solvent.f CH3CN was used as solvent. | |||
1 | FeCl2 | — | 31 |
2 | FeCl3 | — | 31 |
3 | FeBr3 | — | 25 |
4 | FeSO4·7H2O | — | 20 |
5 | Fe(NO3)3·9H2O | — | 20 |
6 | FeCl3·6H2O | — | 35 |
7 | CuCl2 | — | Trace |
8 | PdCl2 | — | Trace |
9 | Ni2Cl·6H2O | — | Trace |
10 | — | — | — |
12 | FeCl3·6H2O | Pyridine | Trace |
13 | FeCl3·6H2O | 1,10-Phenanthroline | Trace |
14 | FeCl3·6H2O | Formic acid | Trace |
15 | FeCl3·6H2O | L-Proline | Trace |
16 | FeCl3·6H2O | H2SO4 | 22 |
17 | FeCl3·6H2O | HNO3 | 25 |
18 | FeCl3·6H2O | HCl | 91 |
19 | — | HCl | 35 |
20c | FeCl3·6H2O | HCl | Trace |
21d | FeCl3·6H2O | HCl | 36 |
22e | FeCl3·6H2O | HCl | 28 |
23f | FeCl3·6H2O | HCl | 40 |
The substrate scope of esterification with alcohols was investigated under the optimized reaction conditions. As shown in Table 2, esterification of benzamide by primary alcohols, secondary alcohols, tertiary alcohols, and ring alcohols took place smoothly, and the corresponding esters were afforded in good to high yields. When primary alcohols 2a, 2b, 2c were used as substrates, affording the ester products 3a–3c in high yields, it should be noted that the reactivity of the alcoholysis of amides was independent of the alkyl chain length (Table 2, entries 1–3). Secondary alcohols 2d and tertiary alcohols 2e also worked effectively as the substrates, producing the esters in 81–91% yield (Table 2, entries 4–5). Treating 1a with cyclohexanol 2f could afford the ester 3f in 80% yield (Table 2, entry 6). Alcoholysis products 3g and 3h were obtained from corresponding alcohols (Table 2, entries 7–8). Substrate alcohol having trifluoromethyl also participated in this catalytic reaction to form the ester 3i in high yield (Table 2, entry 9). Moreover, when ethane-1,2-diol was treated with 1a, only one product 3j was obtained (Table 2, entry 10).
Entry | Alcohol | Products | Yieldb |
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a Reaction conditions: 1a (0.2 mmol), 2a (0.1 mL), 2b–2j (0.24 mmol), FeCl3·6H2O (0.04 mmol, 20 mol%), HCl (0.24 mmol, 36–38%), n-hexane (1.0 mL), 80 °C, 14 h.b Isolated yield. | |||
1 | Ethanol 2a | 3a, 85% | |
2 | n-Propanol 2b | 3b, 88% | |
3 | n-Octanol 2c | 3c, 82% | |
4 | i-Propanol 2d | 3d, 91% | |
5 | t-Butyl alcohol 2e | 3e, 81% | |
6 | Cyclohexanol 2f | 3f, 80% | |
7 | Phenethanol 2g | 3g, 83% | |
8 | Phenethanol 2h | 3h, 81% | |
9 | Trifluoroethanol 2i | 3i, 81% | |
10 | Ethane-1,2-diol 2j | 3j, 85% |
We then examined the generality of amides and the results are compiled in Table 3. Under the optimized conditions, both electron-rich and electron-deficient group substituted benzamide could undergo C–N bond cleavage and esterification by ethanol to afford the corresponding ester products in high yields (Table 3, entries 1–7). Various functional groups such as alkoxy, hydroxyl, amino, halide, and nitro remained intact during the reaction. 2-Naphthamide also served as an efficient substrate and could react with 2a, furnishing the ester 3r in 86% yield. Interestingly, heteroaryl substituted esters 3s and 3t were obtained from the reaction of 2-thiophenecarboxamide and 3-indoleacetamide with 2a using the present reaction conditions, indicating that this method will be an efficient approach to introduce an aromatic heterocycle into functional molecules. Substrates containing alkynes such as cinnamamide (1l) could also react with ethanol smoothly to give an esterification product 3u with 88% yield. The reaction was not sensitive to the steric environment of the amide moiety; when meta- and ortho-substituted amides 1m and 1n were subjected to the reaction system, the corresponding ester products were obtained in high yields.
Entry | Amides | Products and yieldb |
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a Reaction conditions: 1b–1n (0.2 mmol), 2a (0.1 mL), FeCl3·6H2O (0.04 mmol, 20 mol%), HCl (0.24 mmol, 36–38%), n-hexane (1.0 mL), 80 °C, 14 h.b Isolated yield. | ||
1 | 3k, 86% | |
2 | 3l, 85% | |
3 | 3m, 78% | |
4 | 3n, 75% | |
5 | 3o, 86% | |
6 | 3p, 84% | |
7 | 3q, 90% | |
8 | 3r, 86% | |
9 | 3s, 84% | |
10 | 3t, 55% | |
11 | 3u, 88% | |
12 | 3v, 85% | |
13 | 3w, 81% |
In addition to alcohols, esters were also used as substrates for esterification of amides through the acyl–acyl exchange process under the optimal reaction conditions.14 As shown in Table 4, in the current catalytic system, formate, acetate and benzoate also served as efficient substrates and could react with amides, furnishing the corresponding esters in high yield (Table 4, entries 1–7).
The substrate scope of this iron-catalyzed esterification of secondary and tertiary amides with alcohols was investigated. Remarkably, when a secondary amide, viz., N-methylbenzamide (1o) and a tertiary amide, viz., N,N-diethylbenzamide (1p) were used as substrates, the corresponding esters 3a and 3v were afforded in high yield (Scheme 1).
In addition to aromatic primary, secondary and tertiary amides, the esterification of aliphatic primary, secondary and tertiary amides was also investigated under the optimal reaction conditions, the corresponding esters were afforded in good to excellent yield and the results are shown in Scheme 2. 2-Phenylacetamide (1q) participated in this catalytic reaction to form the ester 3y in 86% yield. N-Acetylaniline 1r and N,N-dimethylformamide 1s were also applicable to this catalytic system, and transformed into the corresponding esters 3z and 3z1 in 79% and 82% yield respectively.
To demonstrate the effect of iron salt in the current catalytic system, several control experiments were carried out as shown in Scheme 3. When 1 equivalent FeCl3·6H2O was used as the catalyst in the absence of HCl, 3a was obtained in 90% yield. This result indicated that the catalytic cycle of the iron salt was hindered in the present reaction conditions. When the stronger bidentate ligands such as 2,2-bipyridine was used, 3a was not obtained and trace amounts of 3a were detected on using ferrocene as the catalyst, indicating that the iron salt catalyst showed low efficiency in the presence of the stronger ligand. Thus, it was deduced that free Fe(II or III) was effective for this reaction.
According to the reported literature5d and our experimental results, the catalytic reaction pathways for the Fe-catalyzed esterification of amides by alcohols are proposed as shown in Scheme 4. The first step is the generation of the amidate complex A, which can be formed from free Fe(III) and amide 1. The complex A reacts with alcohol 2 to produce an unstable intermediate B. The interaction between the alcohol oxygen and the carbonyl results in cyclic intermediate C, which is in equilibrium with its isomer D. Intermediate E can also be produced from D via C–N bond cleavage. Through the reaction of HCl and a new molecule amide, intermediate E produces the desired ester 3, ammonium chloride (colorless crystal, which was detected after the reaction), and the amidate complex A.
Footnote |
† Electronic supplementary information (ESI) available. See DOI: 10.1039/c7ra12152k |
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