Issue 5, 2018

Silyl enol etherification by a Tf2NH/amine co-catalytic system for minimizing hazardous waste generation

Abstract

A practical silyl enol etherification of ketones with allylsilanes catalyzed by a Tf2NH–amine co-catalyst under mild conditions has been developed. The reaction generated only volatile isobutene gas as waste. Moreover, a multi-gram synthesis using a microfluidic system and a domino silyl enol etherification–(2 + 2) cycloaddition reaction were demonstrated.

Graphical abstract: Silyl enol etherification by a Tf2NH/amine co-catalytic system for minimizing hazardous waste generation

Supplementary files

Article information

Article type
Communication
Submitted
07 Mar 2018
Accepted
11 Jul 2018
First published
11 Jul 2018

React. Chem. Eng., 2018,3, 626-630

Silyl enol etherification by a Tf2NH/amine co-catalytic system for minimizing hazardous waste generation

K. Kurahashi, Y. Yamaoka, Y. Takemoto and K. Takasu, React. Chem. Eng., 2018, 3, 626 DOI: 10.1039/C8RE00039E

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