A targetable fluorescent probe for dSTORM super-resolution imaging of live cell nucleus DNA

Xiaodong Zhang; Zhiwei Ye; Xinfu Zhang; Huizi Man; Zhenlong Huang; Ning Li; Yi Xiao

doi:10.1039/C8CC08575G

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A targetable fluorescent probe for dSTORM super-resolution imaging of live cell nucleus DNA†

Xiaodong Zhang,‡^a Zhiwei Ye,‡^a Xinfu Zhang,

*^a Huizi Man,^a Zhenlong Huang,^a Ning Li

^a and Yi Xiao

*^a

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* Corresponding authors

^a State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
E-mail: xiaoyi@dlut.edu.cn, zhangxinfu@dlut.edu.cn

Abstract

HoeSR, a nucleus specific probe for dSTORM super-resolution imaging of nucleus DNA in live cells, was designed by conjugating a rhodamine fluorophore and a Hoechst tag. HoeSR labels the cell nucleus in a wash-free way and emits intensive fluorescence exclusively in the nucleus. With the aid of HoeSR, nucleus nanostructures at different mitosis stages were observed through super-resolution imaging.

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Article information

DOI: https://doi.org/10.1039/C8CC08575G
Article type: Communication
Submitted: 26 Oct 2018
Accepted: 16 Jan 2019
First published: 16 Jan 2019

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Chem. Commun., 2019,55, 1951-1954

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A targetable fluorescent probe for dSTORM super-resolution imaging of live cell nucleus DNA

X. Zhang, Z. Ye, X. Zhang, H. Man, Z. Huang, N. Li and Y. Xiao, Chem. Commun., 2019, 55, 1951 DOI: 10.1039/C8CC08575G

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Chemical Communications

A targetable fluorescent probe for dSTORM super-resolution imaging of live cell nucleus DNA†

Abstract

Supplementary files

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A targetable fluorescent probe for dSTORM super-resolution imaging of live cell nucleus DNA

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